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Pcl rehabilitation protocol pdf Rating: 4.5 / 5 (4482 votes) Downloads: 37225 CLICK HERE TO DOWNLOAD . . . . . . . . . . anterior drawer) Patella mobilization Ankle pumps (plantar flexion with resistance band) Hamstring, gastroc-soleus stretches Kevin B. Freedman, M.D. Sports Medicine Old Lancaster Rd, Suite Bryn Mawr, PA Phone: () Fax: () PCL RECONSTRUCTION Phase Iweeks. This protocol provides you with general guidelines for initial stage and progression of rehabilitation according to specified time frames, General Guidelines/ Precautions: ning)PCL brace is to be worn xweeks. PRICE (Protect, Rest, Ice, Compress, Elevate) protocol Avoid hyperextension (weeks) Prevent PCL INJURYNON-OPERATIVE REHABILITATION PROTOCOL WEIGHT BRACE ROM THERAPEUTIC BEARING EXERCISES PHASE Iweeks Progress to weight This protocol is a guide only for isolated PCL injuries that have been appropriately assessed and deemed suitable for conservative management Non-Operative PCL Tear Rehabilitation Protocol. The intent of this protocol is to provide the clinician with a guideline for a non-operative rehabilitation course of a patient with Operative PCL Rehabilitation Protocol. PCL loading occurs at higher knee angles. Maintain strength, endurance, and function, begin sport-specific functional progression (backward running, cutting, grapevine, etc.), progress to running, initiate a plyometric PCL Reconstruction. nerally increase as knee angle regards to squat progression, PCL loading is the least Cincinnati Sportsmedicine and Orthopaedic Center Rehab Protocol: PCL. ROM 0°° (active extension/passive flexion withlb. It is prudent to use smaller knee angles (deg) before progressing to larger knee angles (deg.) because PCL forces. Precautions. NMES Guideline: lateral quadriceps and distal medial quadriceps. (Modify distal electrode placement by not covering superior medial (VMO) arthroscopy This protocol provides you with general guidelines for initial stage and progression of rehabilitation according to specified time frames, related tissue tolerance and PCL RECONSTRUCTION REHABILITATION PROTOCOL WEIGHT BRACE ROM THERAPEUTIC BEARING EXERCISES PHASE Iweeks Nonweight Locked in Advance rehabilitation to competitive sports, usually at months GOALS: Achieve maximal strength and further enhance neuromuscular coordination and endurance Non-Operative PCL Tear Rehabilitation.

Axi4 protocol specification pdf Rating: 4.8 / 5 (2915 votes) Downloads: 4177 CLICK HERE TO DOWNLOAD . . . . . . . . . . Before beginning an AXI design, you need to download, read, and understand the ARM AMBA AXI Protocol v The following changes have been made to this specification. AMBA AXI and ACE Protocol Specification Version E. This site uses cookies to store information on your computer. This guide introduces the main features of Advanced Microcontroller Bus Architecture (AMBA) AXI4, highlighting the differences from the previous version AXIThe guide Part A AMBA AXI3 and AXI4 Protocol Specification Chapter A1 Introduction A About the AXI protocol This specification is written for hardware and software engineers who want to become familiar with the Advanced Microcontroller Bus Architecture (AMBA) and engineers who modules that are compatible with the AMBAAXI4-Stream protocol. If you are not happy with the use of these cookies, please review our Cookie Policy to learn how they can be disabled By continuing to use our site, you consent to our cookies. Using this book This book is organized into the following chapters: ChapterIntroduction Read this for an •Describe the purpose and operation of a bus and communication protocol in an SoC. •Identify the characteristics of various Arm AMBA System Buses including AMBAand any arm technology except the relevant amba specificationthe relevant amba specification is provided “as is” with no warranties express, implied or statutory, AMBA AXI and ACE Protocol Specification Version E. This site uses cookies to store information on your computer. Issues B and C of this document included an AXI specification version, v and v These version number have been discontinued, to remove confusion with the AXI versions, AXI3 and AXIProprietary Notice This guide introduces the main features of Advanced Microcontroller Bus Architecture (AMBA) AXI4, highlighting the differences from the previous version AXIThe guide explains the key concepts and details that help you implement the AXI4 protocol Part A AMBA AXI3 and AXI4 Protocol Specification Chapter A1 Introduction A About the AXI protocolA A AXI revisionsA This book is written for hardware and software engineers who want to become familiar with the Advanced Microcontroller Bus Architecture (AMBA) and engineers who design systems and modules that are compatible with the AMBAAXI4-Stream protocol •Describe the purpose and operation of a bus and communication protocol in an SoC. •Identify the characteristics of various Arm AMBA System Buses including AMBAand AMBA 4, AXI4-Lite, and AXI4-stream. By continuing to use our site, you consent to our cookies • AXI4-Stream removes the requirement for an address phase altogether and allows unlimited data burst size AXI4-Stream interfaces and transfers do not have address A heterogeneous system for offloading Protocol Buffer serialization onto dedicated FPGA hardwarefirework/resources/AMBA AXI and ACE Protocol at Architecture (AMBA ®) ARM AXI4 specifications. •Outline the functionality and characteristics of the Arm AMBA AXI4-Lite and AXI4-stream Note that issue E.a, the first publication of issue E of this specification, was originally identified as issue E. Issues B and C of this document included an AXI specification version, v and v These version numbers have been discontinued to remove confusion with the AXI versions AXI3 and AXIChange history Date Issue Confidentiality (i) use and copy the relevant AMBA Specification for the purpose of developi ng and having developed products that comply with the relevant AMBA Specification; (ii) manufacture and have manufactured products which either: (a) have been created by or for LICENSEE under the All CMSIS Documentation.

Muldowney protocol pdf Rating: 4.6 / 5 (2033 votes) Downloads: 45668 CLICK HERE TO DOWNLOAD . . . . . . . . . . My protocol utilizes manual therapy techniques as well as specific exercises to slowly Every staff member in this facility has been trained personally by Kevin Muldowney on how to use the Muldowney EDS protocol. Some people with EDS do find the Muldowney I’ve heard that the Muldowneys recommend swimming or recumbent bicycles, but neither of those are accessible to me, nor do they solve the energetic dog problem. Their trust in me and willingness to help the greater EDS population is the only way this protocol could have ever been developed.” Kevin Muldowney, MSPT Testimonials from Kevin’s patients He said the main point of the protocol is sloooooowly building up strength and endurance in certain muscles, a tiny I've read about the Muldowney Protocol, but wrote it off because you need a PT that will actually watch you do everything and correct/reset any you movement that your body Is anyone interested in being accountability partners or starting a group chat for doing the Muldowney protocol every day? MFR to all tight muscles that are prohibiting the patient from performing their exercises. This way, every physical therapist understands This will allow people living with EDS to have less pain throughout their body. •PT fix hip and tape hip so patient can get through protocol Muldowney Physical Therapy is redefining how physical therapy should be performed with the Ehlers-Danlos Syndrome (EDS) population. Just hyping each other up, venting, going through the specialized graduated exercise protocol developed by Kevin Muldowney PT, owner of Muldowney physical therapy an outpatient clinic dedicated to EDS treatment Everyone with EDS experiences different symptoms at different degrees. The owner of Muldowney Physical Therapy, Kevin Muldowney, PT, has been treating Physical therapists (also called physiotherapists or PTs) can help people with the Ehlers-Danlos syndromes (EDS) and hypermobility spectrum disorders (HSD) in many ways, depending on the type of pain and other symptoms they have. This means everyone requires different treatments. Teach family to fix SIJ at home. •PT performs MET to SIJ and L5-T8 and ribs. Any insights HOW DO WE USE THE MULDOWNEY PROTOCOL IN OUR CLINIC? What makes the Muldowney Physical Therapy Protocol better than other protocols? A physical therapist can: Prescribe appropriate exercises to reduce pain associated with joint instability, muscle Both clinics are committed to treating people with EDS. Owner, Kevin Muldowney, PT has been achieving excellent results with this population for many years now. Tape low back and SIJ or have patient get an SIJ belt (Don Joy). The exercise protocol outlined in this book was developed by a physical therapist from Rhode Island, This book is intended for the person diagnosed with EDS to both inform them about the healthcare team needed to properly treat them as well as to guide both the physical My old PT followed the gist of it but didn’t follow it directly. Our staff is devoted to helping people with EDS live a better life through manual therapy, physical therapy education and exercise. He has developed a physical therapy protocol designed specifically to allow his patients to rease their pain and increase their overall well-being The exercise protocol outlined in this book was developed by a physical therapist from Rhode Island, Kevin Muldowney, MSPT, who has been treating people with EDS since Kevin has lectured to numerous EDS support groups, as well as, at the Ehlers-Danlos National Foundation Learning Conference “This book is dedicated to all of my patients with EDS who had faith in me and allowed me to work with them to develop this treatment protocol.

Apb protocol specification pdf Rating: 4.6 / 5 (2282 votes) Downloads: 28342 CLICK HERE TO DOWNLOAD . . . . . . . . . . This version of the specification is referred to as APB2 The Advanced Microcontroller Bus Architecture (AMBA) specification defines an on-chip communications standard for designing high-performance embedded microcontrollers. This document is protected by copyright and other related rights and the practice or implementation of the information containe d in this The APB protocol relates a signal transition to the rising edge of the clock to signify the integration of APB peripherals into any design flow. It defines a low-cost interface optimized for minimal power consumption and reduced interface complexityUser APB Interface Timing APB is low bandwidth and low. It addresses high-bandwidth, high-clock-frequency system designs and includes features that make it suitable for high-speed interconnect, typical in mobile and consumer applications Advanced Peripheral Bus (APB) is the part of Advanced Microcontroller Bus Architecture (AMBA) family protocols. This document is only available in a PDF version. This paper introduces the AMBA APB b AMBA APB Protocol Specification. This document is only available in a PDF version. Click Download to view Advanced Peripheral Bus (APB) is the part of Advanced Microcontroller Bus Architecture (AMBA) family protocols. Click Download to view AMBAThe AMBAspecifications introduced more interface protocols on top of the AMBAspecifications, including ACE, the AXI Coherency Extensions. hdmi Specification Licence set about below. The Advanced Peripheral Bus (APB) is part of the Advanced Microcontroller Bus Architecture (AMBA) protocol family. Advanced Microcontroller Bus Architecture (AMBA) Advanced Peripheral Bus (APB) protocol. Using this book This book is organized into the following chapters: Chapter The Advanced Peripheral Bus (APB) is part of the Advanced Microcontroller Bus Architecture (AMBA) protocol family. The design is created using Verilog AMBAAPB Specification The AMBAAPB Specification is detailed in AMBA Specification Rev(ARM IHI A). This specification defines the interface signals, Introduction. architecture. It defines a low-cost interface that is optimized for minimal Missing: pdf APB (Advanced Peripheral Bus) is one of the components of the AMBA bus architecture. It defines a low-cost interface that is optimized for minimal power consumption and reduced interface complexity. APB is low bandwidth and low performance bus used to connect the peripherals like IHIC Amba Apb Protocol SpecFree download as PDF File.pdf), Text File.txt) or read online for free. Three distinct buses are defined within the AMBA specification: •the Advanced High-performance Bus (AHB) •the Advanced System Bus (ASB) •the Advanced Peripheral Bus (APB) Advanced Peripheral Bus ProtocolAdvanced Peripheral Bus Protocol. It defines a low-cost interface optimized for minimal The Advanced Microcontroller Bus Architecture (AMBA) specification defines an on-chip communications standard for designing high-performance embedded microcontrollers AMBA APB Protocol Specification. The users of APB protocols can encounter an application that requires the addition of signaling that is not specified in the APB protocol. performance b us used to connect the peripherals like UA RT, Keypad, Timer and other peripheral devices to the bus. The APB protocol is not pipelined, use it to connect to low-bandwidth peripherals that do not require the high User signaling defines a standard method of adding this signaling to a transaction, without defining the signal usage The AMBAAPB Specification is detailed in AMBA Specification Rev(ARM IHI A). This specification defines the interface signals, the basic read and write transfers, and the two APB components the APB bridge and the APB slave.

Homekit accessory protocol specification pdf Rating: 4.8 / 5 (3309 votes) Downloads: 30642 CLICK HERE TO DOWNLOAD . . . . . . . . . . The HomeKit ADK implements key components of HAP is an implementation of the HomeKit Accessory Protocol specification. It details all the Apple defined services which are HistoryMB. Why? This project was developed with interest in privacy and understanding of how the HomeKit • Full HomeKit Accessory Protocol (HAP) Easy configuration setup User API independent of communications transport Easy porting and adaptation to target Accessories provide one or more services, represented by instances of HMService, that are the features that the user can control, like the light attached to a garage door opener, or This SDK implements the HomeKit Accessory Protocol (HAP) for integration with the accessory’s application software on an ARM® Cortex®-M4-based high-performance Homekit Accessory Protocol R Contribute to seydx/hap-rdevelopment by creating an account on GitHub Your iOS, tvOS, or watchOS app can integrate with HomeKit (and by extension the Home app) to provide a custom or accessory-specific experience. Reload to refresh your session. HAP supports two transports, IP and Bluetooth LE. The information provided in the HomeKit Accessory Protocol Specification (Non You signed in with another tab or window. View the HomeKit Accessory Protocol Specification (Noncommercial Version) Developing apps HomeKit Accessory Protocol (HAP) is Apple’s proprietary protocol that enables third-party accessories in the home (e.g., lights, thermostats and door locks) and Apple products to communicate with each other. You signed out in another tab or window. It allows for the creation of Elixir powered HomeKit accessories which can be controlled from a HomeKit Accessory Protocol based on HAP Specification provided by Apple. Why? This project was developed with interest in privacy and understanding of how the HomeKit Accessory Protocol works to provide safe and secure communication between our iDevices and the server itself Up until now, only companies who intended to distribute their HomeKit-enabled accessories commercially could make use of Apple's HomeKit Accessory Protocol Specification. It details all the Apple defined services which are used in HomeKit devices and the characteristics which are the data that make up the services Note, you need to login with your Apple ID to access the document. MFi licensees get access to the HomeKit Accessory Protocol Specification, HomeKit Accessory Development Kit (ADK), certification tools, and Works with Apple Home badge artwork Download the Accessory Design Guidelines for specifications on using Bluetooth technologies, creating watch bands, designing cases, and more. Note, you need to login with your Apple ID to access the document. Homekit Accessory Protocol R Contribute to seydx/hap-rdevelopment by creating an account on GitHub HomeKit. For example, you can You want the HomeKit Accessory Protocol Specification. Developers had to request licensing through Apple's MFi program and go through reportedly rigorous testing to claim the coveted Works with Apple HomeKit badge You want the HomeKit Accessory Protocol Specification. Reload to refresh your session. You switched accounts on another tab or window HomeKit Accessory Protocol based on HAP Specification provided by Apple. ESP implementation of Apple Homekit Accessory Protocol(HAP)slompf18/esp32_hap rows · The HomeKit ADK is used by silicon vendors and accessory manufacturers to build HomeKit compatible devices. Download the Apple Accessory Design Guidelines. If you plan to develop or manufacture a HomeKit accessory that will be distributed or sold, your company needs to be enrolled in the MFi Program.

Pivotal boost trial protocol pdf Rating: 4.3 / 5 (2114 votes) Downloads: 38777 CLICK HERE TO DOWNLOAD . . . . . . . . . . Disease site: Prostate Missing: pdf 6, · Purpose. Both T2 and DWI are important and this depends on tumour location in the gland. At the site of the dominant The PIVOTALboost trial tests two escalation strategies in a high intermediate to high risk groups with locally bulky prostate tumours PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost. PIVOTALboost is a multicentre four-arm superiority phase III randomised controlled trial (Fig; full protocol provided as appendix A).Eligible patients are allocated to one of the following treatment arms: A: prostate alone IMRT (control), B: prostate and pelvic IMRT, prostate IMRT and prostate boost, prostate and pelvic IMRT and prostate boost A scoreorlesion (clinically significant cancer is likely or highly likely to be present) according to the (PI-RADS (v.2) guidelines. Original Protocol Background: The PIVOTALboost trial (ISRCTN) recruits patients with intermediate and high risk, localised prostate cancer; it tests the role of pelvic node PIVOTALboost is a randomised controlled parallelarm phase III multicentre trial in men with localised high and intermediate risk prostate cancer. DIL with a minimum dimension of 5mm. Localised High Risk Prostate Cancer Trial Questions. Total DIL volume must be <50% total prostate volume Using spacers significantly reduced rectal dose in allpatients in this study. Table of Contents. To establish the toxicity profile of high-dose pelvic lymph node intensity-modulated radiation therapy (IMRT) and to assess whether it is safely A randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the safety and efficacy of secukinumab mg and mg in adult patients A Multicenter, Open-label, Randomized, PhaseTrial to Compare the Efficacy and Safety of Lenvatinib in Combination with Everolimus or Pembrolizumab Versus Sunitinib Alone PIVOTAL is a phase II trial randomising between prostate and prostate + pelvic Intensity Modulated Radiotherapy (IMRT) in patients with locally advanced prostate cancer. Prior to opening to recruitment a contouring QA program was designed aiming to improve consistency in clinical outlining. % atyears. Local recurrence. Methods: Intra-prostatic boosting •PIVOTALboost evaluates benefits/toxicity of pelvic node RT and focal boost dose escalation.•Unfavourable intermediate/high risk and bulky local disease are most likely to benefit.•Functional MRI imaging is used to select patients for different types of dose escalation.•HDR brachytherapy or focal do us@ Dr John Staffurth Clinical co-ordinator (nodal radiotherapy) and translational studies lead Velindre Cancer Centre Cardiff CFTL rth@ Dr Ann Henry Clinical co-ordinator (High dose rate brachytherapy) St James’s University Leeds, LSTFa Look at the staging MRI (suitable boost yes or no)Choose the randomisation option (investigator choice) No boost volume Randomisation optionPelvic node Or Randomisation Option 2a: Pelvic node and whole gland HDR A Boost volume Randomisation Option 2b: Pelvic node and focal boostarm, A vs Barm, A vs B vs C1 vs D1 It was possible to boost DIL toGy to without violating dose constraints inofpatients and to Gy in Trial description: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost Background: The PIVOTALboost trial (ISRCTN) recruits patients with intermediate and high risk, localised prostate cancer; it tests the role of pelvic node radiotherapy and the effectiveness of a focal intra-prostate IMRT boost. Disease free survival. Proactive IV irOn Therapy in haemodiALysis patients (PIVOTAL) PROTOCOL AND STATISTICAL ANALYSIS PLAN. The Missing: pdfAny questions relating to this protocol should be addressed in the first instance to the PIVOTALboost Trial Manager within ICR-CTSU: Email: PIVOTALboost-icrctsu@ General enquiries/ Fax Methods/study design. Consenting patients will be PIVOTALboost Trial Overview.

Crispr protocol pdf Rating: 4.9 / 5 (4520 votes) Downloads: 35438 CLICK HERE TO DOWNLOAD . . . . . . . . . . Table of Contents. μ. Add l of room temperature SOC medium (from. μ. Research laboratory of Xin Chen, PhD. Liver Cancer Laboratory This protocol is recommended for selected cells co-transfected with CRISPR/Cas9 KO Plasmid and HDR Plasmid, and for the removal of genetic material flanked by LoxP sitesone aliquot of Topcells in ice formin, addl of the TOPO cloning reaction. PCR-Blunt II-Topo kit) and incubate at°C with shaking forhr CRISPR DNA vector n Nucleus N u c l e a r l o c al iz t on T r a n s c r i p t i o n C a sTarget R N P c o m p l e x Cas9 Cas9 Cas9 Cas9 cleavage Maximum efficiency, minimal off-target cleavage with CRISPR-Cas9 RNP complex By transfecting Cas9 protein together with the targeting gRNA, we achieve higher cutting efficiencies and lower off Protocol should be used to generate DNA for targeting vector assembly, Southern blotting, or analysis of genomic integrity, and protocols and should be used to screen well plates of clones for desired modifications. Engineered CRISPR systems contain two This volume presents a list of cutting-edge protocols for the study of CRISPR-Cas defense systems and their applications at the genomic, genetic, biochemical and structural levels However, the conventional protocol to introduce the CRISPR/ Cas9 system into iPSCs requires the delivery of Cas9 and guide RNA via viral vectors, RNA, or puri ed Cas Vector preparation: p3I (Thermo Fisher) Water toμlIn a thermocycler°C forhours, inactivate. Heat-shock the cells at°C, then return to ice formin. Protocol can be used as template for the SURVEYOR assay and the in vitro cutting assay with Cas9 protein Engineered CRISPR systems contain two components: a guide RNA (gRNA or sgRNA) and a CRISPR-associated endonuclease (Cas protein). from the previous step, and incubate on ice formin. The RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats (CRISPR) adaptive immune system can be used to facilitate This protocol is a rapid and high-throughput method of generating genomic DNA of sufficient quality to enable screening for small modifications and knock-ins (protocols To download this handbook as a PDF, please visit. KIP the alkaline phosphatase stepUse a The Guide-it CRISPR/Cas9 System (Green, Cat. No. ; Red, Cat. No.) is a complete system for the cloning and expression of a target single guide RNA (sgRNA) CRISPR cloning protocol Zhang · Xin Chen Lab · UCSF. The gRNA is a short synthetic RNA composed of a scaffold sequence necessary for Cas-binding and a user-defined ∼nucleotide spacer that defines the genomic target to be modified t°C formins, keep at 4°C. This handbook describes CRISPR/Cas9 genome Due to its comparative simplicity and adaptability, CRISPR has rapidly become the most popular genome engineering approach.

Bluetooth communication protocol pdf Rating: 4.5 / 5 (4678 votes) Downloads: 47243 CLICK HERE TO DOWNLOAD . . . . . . . . . . The Bluetooth system is operating in the GHz Industrial, Scientific, and Medicine (ISM) band. The Bluetooth Usage Models. Client and server This white paper describes the protocol architecture developed by the Bluetooth Special Interest Group (SIG). The To achieve the highest possible robustness for noisy radio en-vironments, Bluetooth uses a packet-switching protocol based on a frequency hop scheme with hops per The attribute protocol provides means to transmit data between Bluetooth low energy devices. In a single phrase, Bluetooth is a way for devices to communicate with each other wirelessly over short distances. We also thoroughly study prior art that enable advancements in Bluetooth technologies. RF-COMM provides serial cable emulation using a subset of the ETSI GSM standard [2]. Other parts of the Bluetooth Specification deal with interoperability with other protocols and protocol stacks. The architecture and protocols presented in this paper refer to the Bluetooth B Specification released in ember of [2]. It is based upon a lowcost, short-r ange protocols provide different communication abstractions. Further, we also provide an gurations of the physical layer are often referred to as a PHY. Bluetooth Core Specification Version adds a new way. In this paper, a study of Bluetooth protocol and its applications is presented The Attribute Protocol (ATT) is used by an ATT client to discover details of the attribute table in a remote, connected device which is known as the ATT server. Various usage models are presented and complemented with a OUTLINE. The bit channel access code (CAC) must precede all packets exchanged on the piconet channel. Channel access code (CAC): Identifies a piconet based on the master’s ID. Device access code (DAC): Used for special signaling, e.g., paging and response to paging In this paper, a study of Bluetooth protocol and its applications is presented. Defining TCP/IP over Bluetooth requires The Bluetooth Special Interest Group (SIG) is working to impose the Bluetooth technology as the de-facto wire-less standard for personal area wireless communication. A new channel selection algorithm improves the way in which A comprehensive set of documents, called the Bluetooth Specifications, describes in gory detail exactly how they accomplish this, but the basic idea is about wireless, short-range communication. Network Topology: Piconets and Scatternets. The General Bluetooth Architecture: Range and Power. The objective of this paper is to provide At a GlanceEnhanced Attribute ProtocolAn improved version of the Attribute protocol (ATT), called the Enhanced Attribute protocol (EATT), has been introduced along with some associated improvement. to the Generic Attribute Profile (GATT).EATT supports concurrent transactions, allows the interleaving of L2CAP packets relating to ATT packets Three Access codes are defined: n. A comprehensive set of documents, called the Bluetooth Bluetooth is one of the popular technology standards for exchanging data over short distances. The Bluetooth Protocol Stack The Bluetooth Special Interest Group (SIG) is working to impose the Bluetooth technology as the de-facto wire-less standard for personal area wireless communication. Bluetooth devices adopt the bit addressing It relies on a Bluetooth low energy connection and provides procedures to read, The greater majority of Bluetooth LE products either use a combination of connectionless communication (advertising) and point-to-point connections to exchange data or they Bluetooth LE uses adaptive frequency hopping to spread communication across channels in the Ghz band. TODO Understanding Bluetooth as a software developer Developing applications that make use of Bluetooth communication is straightforward and easy The Bluetooth Special Interest Group (SIG) has developed the Bluetooth Specification Version Draft Foundation (thereafter to be referred to as the ”Specification”), that allows for developing interactive services and applications over interoperable radio modules and data communication protocols. FigureThe Bluetooth Low Energy stackextended advertisingThe LE 2M PHY uses a symbol rate ofmega-symbols per second which given that Bluetooth technology uses a binary modulation sche Bluetooth technology architecture and protocols.

Lipofectamine 2000 protocol pdf Rating: 4.5 / 5 (9328 votes) Downloads: 23917 CLICK HERE TO DOWNLOAD . . . . . . . . . . efficient rnai can be achieved by using commercially available trasnfection reagent such as lipofectamine and lipofectamine rnaimax. for each well of cells to be transfected, dilute 0. lipofectamine™ transfection reagent is a versatile transfection reagent that has been shown to effectively transfect the widest variety of adherent and suspension cell lines. with cell number and dna concentration held constant, vary the amount of lipofectamine™ to determine the optimal concentration ( usually 1. dna- lipofectamine® complexes must be made in serum- free medium such as opti- mem® reduced serum medium and can be added directly to cells in culture medium, in the presence or absence of serum. mix gently by rocking the plate back and forth. 75 μl of lipofectamine ltxtm reagent into the above diluted opti- pdf mem® : dna solution, mix gently and incubate 30 minutes at room temperature to form dna- lipofectamine ltxtm reagent. lipofectamine® transfection reagent is a proprietary formulation for transfecting nucleic acids ( dna, rna, and mrna) into a wide range of eukaryotic cells. aspirate medium off cells 3. add 1 μg of plasmid dna into each of the tubes labeled 3: 1 and 6: 1, and 2 μg of dna ( also in a total of 50 μl) into the tube labeled 3: 2. the reagent allows for transfection to be performed both in presence or absence of serum. after the 5- minute incubation, combine the diluted oligomer with the diluted lipofectamine. add 50 μl of dna to the diluted transfection reagent from step 2. lipofectamine™ reagent is sufficient for 500 to 1, 000 transfections in 24- well plates, ortransfections using 6- well lipofectamine 2000 protocol pdf plates. lipofectamine transfection manufacturer lipofectamine 2000 protocol pdf protocol day 0: seed cells onto the wellplates / petridishes to be transfected so that day 1 is at 70- 80% confluence day 1: transfection • vortex and centrifuge dna epps • prepare mix a and mix b for each sample and incubate mixtures separately for 5 min o mix a 6 wellsplate well 10 cm dish. add the oligomer- lipofectamine complexes to each well containing cells and medium. for each well of cells, add 0. 5 μg of dna in 100 μl of opti- mem® i reduced serum media without serum. sirna/ chimera transfection. nucleic acid- lipofectamine® complexes can be added directly to cells in culture medium, in the presence or absence of serum/ antibiotic. tap the tubes or vortex for 1 sec to mix the contents and incubate for 15 – 45 min at room temperature. researchers use lipofectamine™ reagent 2000 for sirna- and shrna- based gene knockdown experiments, as well as for gene expression studies. mix gently and incubate for 20 minutes at room temperature ( solution may appear cloudy). incubate 2000 30min at 37° c while mixing following components in hood ( see spreadsheet for amounts, this example is for one 10cm. make sufficient 10% fbs in opti- memmedia ( w/ oantibiotics) sterile filter 2. add 2- 3 ml pbs to wash 4. the easy protocol, exceptional plasmid dna delivery, and the ability to. to optimize the amount of lipofectamine™ for transfection in a 24- well plate, start with cells at > 90% confluency and pdf use a fixed amount of dna ( 0. it is not necessary to remove complexes or. successful transfection every time unmatched versatility, high efficiency with transfection success across multiple cell lines, lipofectamine™ gives you the most versatile route to. product lipofectamine® reagent is a proprietary formulation description for transfecting nucleic acids into a wide range of eukaryotic cells. with lipofectamine. aspirate off pbs 5. sirna/ chimera should be stored at 4° c and at - 20° c in case of dried and soluble forms respectively, but should not be refrozen for reuse. ( 10 μl) should be made. add 8 ml of 10% fbs/ opti- mem media / plate 6.

Gmlan protocol pdf Rating: 4.9 / 5 (8730 votes) Downloads: 78226 CLICK HERE TO DOWNLOAD . . . . . . . . . . pdf - free download as pdf file (. the idle level, which is approximately 2. this logical grouping may extend across many switches. “ start” ( windows 7 logo) — control panel — programs and features — right click on “ data bus diagnostic tool” and select “ uninstall” from the drop down menu. gmlan ( can bus gm) pdf | pdf | computer network | hybrid vehicle. section ‘ x’ contents. for should explicitly. reading all module parameter identi cations ( pids) scan tool output operations. although it is can based, there are enough proprietary features and functions to make this a unique protocol. gmlan was introduced on the following models ( only the first year of use is listed) : – ion. the low speed gm lan is a single- wire circuit that replaced the class 2. it supports all legislated obd- ii protocols, as well as two proprietary networks: gm single wire can ( gmlan), and ford medium speed can ( ms can). high- speed versions: 100 mbps - fast ethernetmbps - gigabit ethernet ( 1998). this specification establishes the enhanced diagnostics strategy for the gm in- vehicle local area network subsystem, gmlan. vlan best practices. all frames for some. it was standardized as sae j2411 for use in obd- ii vehicle networks. the faster gmlan network operates at 500 kilobytes per second ( kbps), while the slower class 2 network pokes along at 10. general motors local area network ( gmlan) single wire controller area network ( swcan) physical and data link layers specification. it enables different electronic control units ( ecus) within a vehicle to exchange. a vlan is a logical grouping of two or more devices. txt) or read online for free. reliably capture data, including audio and video, with intrepid’ s family of data loggers. general motors local area network enhanced diagnostic test mode specification. the mid speed gm lan bus is termi- nated with resistors. there are essentially two events that must take place to communicate with a sleeping node. pdf), text file (. activate, deactivate, and reprogram loggers remotely. the pinout should fit 47 devices/ models. implementation of this strategy is required for all electronic control units ( ecu) connected to the network. all frames for other. vlan- aware station. gmlan is the general motors variation of the can bus. the high speed gmlan is a differential bus. access link: contain all frames on access. reading and clearing dtcs. first you must wake it up by sending a high voltage wake- up. this document specifies the physical layer requirements for a carrier sense multiple access/ collision resolution ( csma/ cr) data link which operates on a single wire medium to communicate. message transmission protocols that the high speed system does. features: instrument panel cluster response to can. gm cars produced inuse j1850- vpw interface or can. general motors local area network ( gmlan) is an application- and transport- layer protocol using controller area network for lower layer services. the data bus diagnostic tool can be uninstalled by using the following steps: for windows 7. promoted and used by dec, ibm and xerox in 1980s. computer science, engineering. most gm cars produced inuse j1850- vpw interface. low speed general motors local area network ( gmlan) networks are no longer used in vip vehicles. this specification establishes the communication strategy for the gm in- vehicle local area network ( gmlan) subsystem. this strategy is required to be implemented by any node diagnosed on any of. the vip architecture communication protocol is based on the widely used can ( controller area network) protocol. bias incident response protocol. hybrid link: contains and vlan- unaware. 5 volts, is considered recessive transmitted data and is interpreted as a logic 1. classroom management program ( cmp) compatible. different vlans on the different options. uninstallation of the data bus diagnostic tool. set of protocols at the physical and data link layer ( mac sublayer) developed by robert metcalfe, at xerox, in 1970s. 10 mbps ethernet became an ieee standard in 1985 – ieee 802. gmlan ( can bus gm). our loggers support nearly every protocol, including xcp, ccp, iso14229 ( uds), gmlan and more. pinout may be slightly different - depending on model. gm uses network management on their single wire or low speed network in order to wake up nodes that are in a low- current or sleep mode. wireless fleet data logging. the high speed gmlan serial data bus ( + ) and high speed gmlan serial data ( - ) are driven to opposite extremes from a rest or idle level. on the cadillac, the fast can network is called the gmlan protocol pdf gmlan network ( general motors local area network), and the slower one is called the “ class 2” network. the gmlan protocol is a communication protocol developed by general motors for in- vehicle networking. the devices are grouped based on a number of factors depending on the configuration of the network. courseware included: student manual, instructor guide, service information. the mid speed bus consists of a twisted wire pair that transmits a voltage signal that switches high and low to create the data signal. support for non- legislated protocols ( not available in all devices) : o isoraw can) o sae j2818 o sae j2411 ( gmw3089, single wire can, gmlan) o ford ms- can ( medium speed can) • superior automatic protocol detection algorithm • large memory buffer • voltage input for battery monitoring tagging rules ( cont) on a given lan segment gmlan protocol pdf vlan, all frames implicitly or. a vehicle- bus interface ( vbi) that allows us to collect test data directly from a vehicle’ s nodes via the gmlan network with a gm standard thermal instrument ( sti) and facilitates vehicle testing by greatly reducing the need for external sensors and transducers. as with any networking technology, it is important to understand the operational characteristics of vlans if they gmlan protocol pdf are. faster gmlan network at 500 kbs to collect a wealth of data from sensors and controllers that already ex- ist on the vehicle. this paper introduces a vehicle- bus interface ( vbi) that allows gm’ s standard thermal in- strument ( sti) to collect data by interacting with the nodes on the gmlan network that is already on some. most cars produced after are equipped with can bus. high and low speed communications.

Brentuximab avd protocol pdf Rating: 4.8 / 5 (2929 votes) Downloads: 12925 CLICK HERE TO DOWNLOAD . . . . . . . . . . if stevens- johnson syndrome occurs, discontinue brentuximab vedotin. orally 30 minutes prior to brentuximab vedotin. hold brentuximab vedotin if pml is suspected. brentuximab vedotin is an anti- cd30 antibody– drug conjugate that has been approved. days : brentuximab vedotin 1. dacarbazine 375 mg/ m2iv infusion in 1000 ml sodium chloride 0. hold brentuximab vedotin if suspected pancreatitis and discontinue if confirmed. 9% iv infusion over > 1 hour. day 1 day 1 day 1 day 1. brentuximab vedotin ( adcetris) 1. 2 mg/ kg in sodium chloride 0. gov identifier: nct. o serum potassium less than 3. brentuximab vedotin in combination with chp. 2 mg/ kg route: intravenous once over 30 minutes for 1 dose offset: 2 hours instructions: max dose = 180 mg. 300mg daily for cycle 1 only unless otherwise indicated in tls risk assessment. 5) in the a+ avd group and 89. 127 brent- chp authorised by lymphoma lead prof graham collins date: july published: july review: july version 2. methods breach is a multicenter, randomized, open- label, phase ii. all doses will be automatically rounded that fall within ccmb approved dose bands. the 6- year overall survival estimates were 93. acute pancreatitis including fatal outcomes, has been reported in patients who pdf have received brentuximab vedotin. purpose to improve curability and limit long- term adverse effects for newly diagnosed early- stage ( es), unfavorable- risk hodgkin lymphoma. 9% over 10 minutes. 2 mg/ kg; maximum dose 120 mg iv in normal saline 100 ml over 30 minutes. protocol protocol for: castellino sm, pei q, parsons sk, et al. rule- based template: rule oncbcn brentuximab 1. refer to the tumour lysis syndrome in adults protocol ( h. outpatient electrolyte replacement protocol treatment conditions 39 interval: - - occurrences: - - comments: potassium ( normal range 3. 650 mg orally 30 minutes prior to brentuximab vedotin. purpose the prognosis of patients with early- stage unfavorable hodgkin lymphoma remains unsatisfactory. doxorubicin 25 mg/ m2 iv bolus. 0meq/ l) o protocol applies for scr less than 1. vinblastine* * 6 mg/ m2 iv infusion in 50 ml sodium chloride 0. data and adherence of the trial to the protocol,. depending on additional risk factors – consider co- trimoxazole 480 mg daily on monday/ wednesday / friday for the duration of treatment and 3 months following completion. brentuximab vedotin. we conducted an open- label, multicenter, randomized phase 3 trial involving patients with previously untreated stage iii or iv classic hodgkin’ s lymphoma, in which 664 were assigned to receive brentuximab vedotin, doxorubicin, vinblastine, and dacarbazine ( a+ avd) and 670 were assigned to receive doxorubicin, bleomycin, vinblastine, and dacarbazine ( abvd). 0meq/ l, give 40meq kcl iv or po and contact md/ np. we assessed the efficacy and safety of brentuximab pdf vedotin plus doxorubicin, vinblastine, and dacarbazine ( bv- avd) in previously untreated, early- stage unfavorable hodgkin lymphoma ( clinicaltrials. n engl j med ; 387:. brentuximab vedotin ( adcetristm) clinical study protocol c25003, eudract: protocol summary study title: a randomized, open- label, brentuximab avd protocol pdf phase 3 trial of a+ avd versus abvd as frontline. brentuximab vedotin 1. 9% over 30 minutes. 16, 17 the echelon- 1 trial, which evaluated the bv- avd regimen in the first- line treatment of advanced- stage hodgkin lymphoma, dem- onstrated better tumor control with a significant improve- ment in pfs in favor of the bv- avd arm compared with abvd. progression- free survival was longer with a+ avd than. 2mg/ kg conditions: modifications: kg > = 150 kg set dose to 180 mg kg < 150 kg set dose to 1. otherwise, contact md/ np o protocol applies only to same day lab value. methods in this multicenter study with four sequential cohorts, patients received four cycles of brentuximab vedotin ( bv) and doxorubicin, vinblastine, and dacarbazine ( avd). 5- year follow up of the phase 1 data showed a complete remission rate and an event free survival superior to abvd historical controls, which was the impetus for the brentuximab vedotin– avd versus abvd phase 3 echelon- 1 study in. pdf 2 mg of brentuximab vedotin. 2mg/ kg iv over 30 minutes + doxorubicin 25mg/ m 2 iv push + vinblastine 6mg/ m 2 iv over 5– 10 minutes + dacarbazine 375mg/ m 2 iv over 60 minutes. kerry savage or tumor group delegate atorwith any problems or questions regarding this treatment program. dose of brentuximab vedotin of 1· 2 mg/ kg given in combination with avd with a manageable toxicity profile. this is a controlled document and therefore must not be changed or photocopied. brentuximab + avd x 2 cycles pet- ct- 2 pet- ct- 4 biopsy bx- bx+ no further treatment treatment failure, off study brentuximab + avd x brentuximab avd protocol pdf 2 cycles memorial sloan kettering cancer center irb number: a( 19) approval date: 17- aug- the phase 3 echelon- 1 study demonstrated that brentuximab vedotin ( a) with doxorubicin, vinblastine, and dacarbazine ( avd; a+ avd) exhibited superior modified progression- free survival ( pfs) vs doxorubicin, bleomycin, vinblastine, and dacarbazine ( abvd) for frontline treatment of patients with stage iii/ iv classical hodgkin lymphoma ( chl). 7) in the abvd group. avd) regimenwitha5- yearfailure- freesurvivalrateof92% and a 5- year os rate of 100%. if positron emission tomography ( pet) - 4– negative, patients received 30- gy. receive a+ avd ( 1. 9% 100 ml ivpb dose: 1. stevens- johnson syndrome: stevens- johnson syndrome has been reported with brentuximab vedotin. brentuximab vedotin with chemotherapy in pediatric high- risk hodgkin’ s lymphoma. 9% over 1- 2 hours.

Emdr migraine protocol pdf Rating: 4.5 / 5 (7161 votes) Downloads: 80698 CLICK HERE TO DOWNLOAD . . . . . . . . . . with formatting and design by katy murray, msw, licsw, bcd. compiled by beverlee laidlaw chasse, mc, lpc. keywords: emdr; migraine; emdr headache protocol c hronic headaches are one of the most com- mon and disabling problems that a person can have. floatback procedure ( docx) download. modified emdr resource development & installation protocol janina fisher, ph. the journal of emdr practice and research is a peer- reviewed publication devoted to integrative, state- of- the- art papers about eye movement desensitization and reprocessing. however, sometimes pain can continue longer than expected. all you need to do is tell me about what you are experiencing so i can make the proper choices. the breathing helps stimulate the parasympathetic nervous system, which brings on a relaxation response. emdr assessment, resourcing and reprocessing will be reviewed and can be used in person or via telehealth. forty- three individuals diagnosed with classic or common migraine headache were randomly assigned to either phase 1 of integrated eye movement desensitization reprocessing ( emdr) treatment or a standard. the trauma center, boston, ma center for integrative healing, watertown, ma [ this protocol, adapted from the emdr resource development emdr migraine protocol pdf and installation protocol developed by korn & leeds ( ), is intended to facilitate the development of internal resources and. then focus on memories: first, traumatic events unrelated to headaches between the first and the last. emdr- preci— protocol for recent critical incidents 4. unique standardized set of procedures and clinical protocols which incorporates dual focus of attention and alternating bilateral visual, auditory and/ or tactile stimulation 2. for example: pain can occur for many reasons, pain is normally a signal that something is wrong. based on available relevant research, treatment fidelity to the 8 phases emdr migraine protocol pdf ( shapiro,. diaphragmatic breathing is used in integrated emdr ( iemdr) to stimulate the parasympathetic nervous system to initiate the relaxation response. there is some preliminary evidence that emdr may be effective and useful as an alternative treatment for migraine, with a significant decrease in headache frequency and duration with no reduction in pain intensity. it is a broadly conceived interdisciplinary journal that stimulates and communicates research and theory about emdr, and their application to clinical practice. flashforwards protocol - worksheet ( doc) download. identify the 3 essential elements of an integrated emdr approach for stopping an acute migraine or tension headache. integrated emdr treatment reduced or eliminated migraine pain with greater rapidity and showed significantly greater improvement compared to standard care medication immediately posttreatment. then traumatic events before the first remembered event. emd telescopic approach - worksheet ( doc) download. ( abuse, violence, neglect etc. erp— emergency response procedure 2. steve marcus’ migraine headache protocol is an effective, medication free protocol which treats migraine headaches swiftly and efficiently. mp is emdr basic procedural steps what is emdr? emdr eight phase protocol ( doc) download. emdr therapy is a good fit, and begin to. phase 1 treats the headache and phase 2 treats the possible trauma/ distress behind the the pdf migraine headache ultimately curing your migraine. how to treat a headache during any of the 8 phases of the standard emdr protocol. emdr- er— emergency room and wards protocol 3. contents protocol tables for eeis pages 2- 11. shapiro’ s ( ) recent traumatic events protocol and the observations of ignacio jarero and lucina artigas during their many years of experience working in the field with natural or human provoked disasters survivors in. purchase the recording of the webinar that was held on friday,. , ), patients suffering from chronic migraine followed an emdr headache protocol that targets disturbing events related to the headache pdf episodes. phase 2 utilizes the standard emdr protocol in its entirety. to early emdr intervention protocols. in phase 1, the bi- lateral stimulation ( eye movements) is extracted from the standard emdr protocol. pain protocol - worksheet ( doc) download. elizabeth handy septem. overview protocol for multi- session headache treatment. long- term pdf pain can lead to changes in the nervous system, which can maintain the pain. emdr standard procedure worksheet client name _ _ _ _ _ date _ _ _ _ _ instructions: “ every so often i will do a simple check on what you are experiencing. thematic emdr - worksheet ( doc) download. the emdr protocol for recent critical incidents ( emdr- preci) and ongoing traumatic stress is based on dr. during phase 1, which is the focus of this study, we deviate from the standard emdr protocol because of the patient s urgent need for aborting the debilitating pain of acute migraine. practicum: learn to stop an acute migraine headache in your office. it is a two phase protocol. the world health organization. this webinar covers the fundamentals of headache assessment and treatment as well as how to apply the 8 phase emdr approach for headache treatment. ) triggers: out of a list of triggers begin with the ones client come. emdr therapy has been. recognized as an effective treatment for trauma by many organizations including: after you and your therapist agree that. across frequently and ones with high suds. this pilot study was conducted at gaziosmanpaşa hospital, istanbul, to investigate the effectiveness of eye movement desensitization and reprocessing ( emdr) on migraine headache by. extensively researched and is. attention will be given to an image, beliefs, feelings, and. work together, you will be asked to focus on a specific event. in the article another protocol was mentioned: marcus ( ) developed a migraine treatment combining eye movements and diaphragmatic breathing, plus cranial compression – modifying the emdr protocol. an example of an emdr- related protocol in the fi eld of mus is the protocol used in the rct of marcus ( ) for acute migraine headaches; in that study diaphragmatic breathing, cranial. future template- script+ instruct ( pdf) download. this training manual was originally developed by a task group comprised of emdr migraine protocol pdf members of the international society for the study of trauma and dissociation. furthermore, marcus ( ) developed a migraine- specific abortive treatment combining eye movements with diaphragmatic breathing and cranial compres- sion although the full emdr protocol was not used. preamble: prior to commencing reprocessing, explain pain in terms of information processing model. there is no right or wrong way to do emdr. in the second group study ( konuk et al.

Mini hyper-cvad protocol pdf Rating: 4.8 / 5 (3541 votes) Downloads: 8382 CLICK HERE TO DOWNLOAD . . . . . . . . . . Results from the pediatric oncology group and St. Jude Children’s Research Hospital. Two months after the first cycle, the patient was given CODOX-M; however, the vincristine component was changed to etoposide. Dosemg everyhours fordoses, then everyhours until methotrexate level is less than micromol/L. Practical management of anticipated toxicities and treatment of spe Hyper-CVAD is a combination of chemotherapy given with a steroid drug. CT scan (chest and abdomen) was performed for confirmation of extramedullary disease. Methods: Pts ≥years with newly hyper CVAD. RESULTS: The mean age of study population was ±Starthour from start of methotrexate infusion. The age-adjusted hyperCVAD and a lower pegaspar-gase dosage (IU/m2; maximum IU) is used for these patients (Table 2) Short NJ, Kantarjian H, Ravandi F. Updated results of a phase II study of reduced-intensity chemotherapy with mini-hyper-CVD in combination with inotuzumab ozogamicin, with or without blinatumomab, in older adults with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic leukemia In a phase II study evaluating mini-hyper-CVD (a lower intensity version of the hyper-CVAD regimen without anthracycline) in combination with inotuzumab ozogamicin with or without blinatumomab in patients agedyears or older, the MRD negativity rates were% at CR and% overall To further improve outcomes in patients with R/R B cell ALL and reduce toxicity, inotuzumab and blinatumomab have been strategically incorporated into a mini-hyperCVD (mini-HCVD) chemotherapy backbone Mini-Hyper-CVD (cyclophosphamide and dexamethasone at% dose reduction, no anthracycline, methotrexate at% dose reduction, cytarabine at% dose reduction) was combined with inotuzumab during the firstcourses Hyper-CVAD: a regimen for all seasons The major therapeutic advances in acute lymphoblastic leukaemia in adults have occurred in discrete stages over the past three ades. Long-term follow-up results of hyperfractionated Optimal administration of the hyperCVAD regimen requires awareness of its appropriate administration and supportive care practices. The hyperCVAD combination alternating with high-dose methotrexate (MTX) and cytarabine for a total ofintensive courses was first described in The initial In a phase II study evaluating mini-hyper-CVD (a lower intensity version of the hyper-CVAD regimen without anthracycline) in combination with inotuzumab ozogamicin with Without an overactive kinase to target, multiple trials of “traditional” chemotherapy designed specifi cally for older adults were undertaken with disappointing results: persistent high Mini-HCVD (cyclophosphamide and dexamethasone at% dose reduction, no anthracycline, methotrexate at% dose reduction, cytarabine at g/m2 fordoses) Aims: To evaluate the combination of low-intensity chemotherapy and INO with or without Blina, in older pts with newly diagnosed B-ALL. Hyper-CVAD is used to treat some types of non-Hodgkin lymphoma (NHL) and acute lympho-blastic leukaemia (ALL).It is best to read this information with our general information about chemotherapy, steroids and the type of cancer you haveHyper is short for “hyper 6, · Patients were undergone treatment with hyper CVAD regimen according to the standard protocol. Administration: Give intravenous boluses for at least the firstdoses then change to oral if the patient is compliant and not vomiting Patients ≥years of age who are diagnosed with T cell ALL are treated similarly to younger patients with a com-bination of hyperCVAD, nelarabine, and asparaginase. First, the application of intensive, prolonged, multiagent systemic and CNS-directed therapy that was pioneered in children was shown to benefit older patients with acute Complete or partial remission rate was checked aftersession of hyper CVAD regimen. Diffuse small non-cleaved cell lymphoma in children, Burkitt’s versus non-Burkitt’s types. This regimen was well tolerated Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.